2026-UKCEH02 Who’s Alive and Kicking in the Soil? Uncovering Active Microbes

PROJECT HIGHLIGHTS

  • Addresses one of the biggest unknowns in soil science: which microbes are truly active, and when? 
  • Uses three cutting-edge labelling approaches: Stable Isotope Probing (SIP), BONCAT, and heavy water labelling, to directly compare how we detect and measure microbial activity. 
  • Links molecular ecology with global challenges in food security, soil health, and climate resilience. 

Overview

Healthy soils underpin life on Earth. They recycle nutrients, store carbon, support biodiversity, and drive crop productivity. Yet, despite soils harbouring the most diverse microbial communities on the planet, we still know remarkably little about which microbes are actually active and contributing to these vital processes at any given moment. Identifying active microbes, the ones “alive and kicking” is crucial for understanding how soils respond to climate change, land-use pressures, and agricultural management. 

This PhD project will pioneer a direct comparison of three of the most exciting methods currently available for detecting microbial activity in soils: 

  1. Stable Isotope Probing (SIP): Tracks microbes that actively incorporate labelled substrates (e.g., 13C or 15N).
  2. BONCAT (Bioorthogonal Non-Canonical Amino Acid Tagging): Labels translationally active cells by incorporating artificial amino acids.
  3. Heavy Water (²H₂O) Labelling: Identifies growing cells through incorporation of deuterium into biomolecules.

By systematically comparing these approaches across soils and plant rhizospheres, the student will establish how different methods complement or contradict each other, and how they can be used together to build a robust picture of microbial activity. Importantly, this project will connect activity data with forthcoming metatranscriptomic datasets from the DECODing Biodiversity project, enabling novel insights into which microbes are not just present, but contributing functionally at ecosystem scales. 

Research Aims 

  1. To evaluate and compare SIP, BONCAT, and heavy water labelling approaches for detecting microbial activity in soils and rhizospheres.
  2. To link activity profiles to metatranscriptomic data, revealing which microbes are actively contributing to nutrient cycling and plant interactions.
  3. To test how environmental factors (e.g., soil type, moisture, plant genotype) shape the identity and function of active microbial populations.
  4. To establish a methodological framework for future soil microbiome studies that moves beyond presence/absence to real-time activity.

This project is a CENTA Flagship Project.

Case funding

This project is not suitable for CASE funding

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  • Experimental Design: Laboratory incubations of agricultural and semi-natural soils, plus rhizosphere samples from crop systems. 
  • Labelling Approaches: SIP with 13C/15N substrates; BONCAT with artificial amino acids; ²H₂O labelling to track microbial growth. 
  • Detection & Analysis: Flow cytometry and sequencing of labelled populations; shotgun metagenomics and metatranscriptomics; qPCR for targeted traits. 
  • Integration with DECODing Biodiversity data: Comparative analyses using state-of-the-art bioinformatics pipelines, linking active taxa to transcriptomic profiles. 
  • Comparative Assessment: Evaluate strengths, limitations, and complementarity of methods in detecting activity, growth, and functional roles. 

DRs will be awarded CENTA Training Credits (CTCs) for participation in CENTA-provided and ‘free choice’ external training. One CTC can be earned per 3 hours training, and DRs must accrue 100 CTCs across the three and a half years of their PhD.  

The student will gain: 

  • Hands-on expertise in cutting-edge molecular microbial ecology (SIP, BONCAT, heavy water labelling). 
  • Training in metagenomics, metatranscriptomics, and advanced bioinformatics. 
  • Skills in microbial physiology, soil science, and crop–microbe interactions. 
  • Experience with flow cytometry, isotope labelling, and computational analysis pipelines. 
  • Professional development via CENTA cohort training, UKCEH training schools, and international collaborations. 

This project will be delivered in collaboration with the Defra Centre of Excellence (CoE), providing a strong policy and stakeholder interface. The CoE will act as the CASE partner, offering access to policy-relevant datasets, perspectives on soil monitoring, and opportunities to engage with decision-makers. UKCEH provides world-leading expertise in microbial ecology, isotope labelling, and environmental bioinformatics, while academic partners contribute specialist knowledge in soil and plant–microbe interactions. The collaboration ensures the student gains experience in both cutting-edge research and policy-relevant applications, strengthening pathways from discovery science to evidence-based decision-making on soil health and microbial activity. 

Over three years, this PhD will focus on both research and professional development. In Year 1, the student will complete an in-depth literature review and build laboratory and computational skills, piloting SIP, BONCAT, and D₂O labelling approaches in controlled soils. Year 2 will centre on full-scale laboratory experiments, data generation (including integration with metatranscriptomics from the DECODing Biodiversity project), and presentation of initial findings at conferences. In Year 3, the focus will shift to advanced data analysis, cross-method comparison, ecological synthesis, and preparation of manuscripts and the thesis. Across all years, personal and professional development will be prioritised, including networking, society memberships, teaching opportunities, leadership activities, and workshops on grant writing, project management, and career planning. Together, these activities will ensure that the candidate develops into a skilled, confident researcher ready for a successful post-PhD career, while delivering cutting-edge insights into active soil microbiomes. 

Further details and How to Apply

 For any enquiries related to this project please contact Susheel Bhanu Busi, [email protected]. 

The successful applicant would be registered at the University of Warwick. 

To apply to this project: 

  • You must include a CV with the names of at least two referees (preferably three) who can comment on your academic abilities.  

 

 Applications must be submitted by 23:59 GMT on Wednesday 7th January 2026. 

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